Different Approaches to Endophenotypes in Schizophrenia
نویسندگان
چکیده
منابع مشابه
Convergent Approaches for Defining Functional Imaging Endophenotypes in Schizophrenia
In complex genetic disorders such as schizophrenia, endophenotypes have potential utility both in identifying risk genes and in illuminating pathophysiology. This is due to their presumed status as closer in the etiopathological pathway to the causative genes than is the currently defining clinical phenomenology of the illness and thus their simpler genetic architecture than that of the full sy...
متن کاملNeurophysiological endophenotypes across bipolar and schizophrenia psychosis.
The search for liability genes of the world's 2 major psychotic disorders, schizophrenia and bipolar disorder I (BP-I), has been extremely difficult even though evidence suggests that both are highly heritable. This difficulty is due to the complex and multifactorial nature of these disorders. They encompass several intermediate phenotypes, some overlapping across the 2 psychotic disorders that...
متن کاملEvaluating Different Approaches to Permeability Prediction in a Carbonate Reservoir
Permeability can be directly measured using cores taken from the reservoir in the laboratory. Due to high cost associated with coring, cores are available in a limited number of wells in a field. Many empirical models, statistical methods, and intelligent techniques were suggested to predict permeability in un-cored wells from easy-to-obtain and frequent data such as wireline logs. The main obj...
متن کاملStructural cerebral variations as useful endophenotypes in schizophrenia: do they help construct "extended endophenotypes"?
Endophenotypes represent intermediate phenotypes on the putative causal pathway from the genotype to the phenotype. They offer a potentially valuable strategy to examine the molecular etiopathology of complex behavioral phenotypes such as schizophrenia. Neurocognitive and neurophysiological impairments that suggest functional impairments associated with schizophrenia have been proposed as endop...
متن کاملEndophenotypes in Studies of the Genetics of Schizophrenia
The power and appeal of the molecular biology mantra, ‘‘DNA to RNA to protein,’’ to explicate cell biology comes from its universal appearance and application in all species, from microorganisms to human beings. Based on this mantra, the genomes of viruses, bacteria, fruit flies, and now humans are being mapped and sequenced, so that all the genes and, ultimately, their corresponding biological...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Acta Neuropsychiatrica
سال: 2006
ISSN: 0924-2708,1601-5215
DOI: 10.1017/s0924270800032282